Publications

Recent Publications

  1. Chronic second-by-second measures of L-glutamate in the CNS of freely moving rats. Rutherford EC, Pomerleau F, Huettl P, Stromberg I and Gerhardt GA. J Neurochem (in press), Feb. 2007.
  2. Validation studies of the human motor activities panel for Hand/Arm Performance. Smith CD, Walton A, Slevin JT, Gerhardt GA, Umberger G, Smoot K, Schulze E and Gash DM. J Neurosci Meth (in press), 2007.
  3. Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats. Stanford JA, Salvatore MF, Joyce BM, Zhang H, Gash DM and Gerhardt GA. Neurobio Aging 28:156-165, 2007.
  4. Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys. Cass, WA, Grondin R, Andersen AH, Zhang Z, Hardy PA, Hussey-Andersen LK, Rayens WS, Gerhardt GA and Gash DM. Neurobiology of Aging 28(2):258-71, 2007.

Publications (2006)

  1. Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Joyce BM, Glaser P, and Gerhardt G. Psychopharmacology Oct 10, 2006; [Epub ahead of print]
  2. Second-by-second measurement of acetylcholine release in prefrontal cortex. Bruno JP, Gash C, Martin B, Zmarowski A, Pomerleau F, Burmeister J, Huettl P and Gerhardt GA. Eur J Neurosci. 24(10):2749-57, 2006.
  3. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. Zhang Z, Andersen AH, Ai Y, Loveland A, Hardy PA, Gerhardt GA and Gash DM. Neuroimage 33(2):636-43, 2006.
  4. Reduced Plasma Membrane Surface Expression of GLAST Mediates Decreased Glutamate Regulation in the Aged Striatum. Nickell JR, Salvatore MF, Pomerleau F, Apparsundaram S and Gerhardt GA. Neurobiology of Aging (in press) [Epub ahead of print] Sep 5 2006.
  5. Point source concentration of GDNF may explain failure of Phase II clinical trial. Salvatore MF, Ai Y, Fischer B, Zhang AM, Grondin RC, Zhang Z, Gerhardt GA and Gash DM. Exp Neurol 202(2):497-505, 2006.
  6. Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, and Young AB. Neurosurg Focus 20(5):E1, 2006.
  7. Reply: GDNF poses troubling questions for doctors, drug maker. Slevin JT, Gerhardt GA, Smith CD, Gash DM, and Young AB. Ann Neurol. 59(6):989-990, 2006.
  8. MRI Volumetric and intensity analysis of the cerebellum in Parkinson’s disease patients infused with glial-derived neurotrophic factor (GDNF). Chebrolu H, Slevin JT, Gash DM, Gerhardt GA, Young BA and Smith CD. Exp Neurol 198(2):450-6, 2006.
  9. Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain. Day BK, Pomerleau F, Burmeister J, Huettl PF, and Gerhardt GA. J Neurochem Mar;96(6):1626-35, 2006.
  10. GDNF in treatment of Parkinson's disease: response to editorial. Penn R, Dalvi A, Slevin J, Young B, Gash D, Gerhardt GA, Hutchinson M. The Lancet Neurology, 5(3): 202-203, 2006.
  11. Towards a neuroscience of attention-deficit/hyperactivity disorder: Fractionating the phenotype. Castellanos FX, Glaser PEA and Gerhardt GA. J Neurosci Methods. Feb 15;151(1):1-4, 2006.
  12. Does dopamine neurotransmission occur in the cerebellar vermis? Cerebellar neurotransmission in attention-deficit/hyperactivity disorder. Glaser PEA, Surgener SP, Grondin R, Gash CR, Palmer M, Castellanos FX and Gerhardt GA. 2006 J Neurosci Methods Feb 15;151(1):62-67, 2006.
  13. Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice. Fernandez E, Koek W, Ran Q, Gerhardt GA, France CP and Strong R. Alcohol Clin Exp Res 30(10):1650-8, 2006.

Publications (2005)

  1. Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of the NMDA glutamate receptor. Ledo A, Barbosa RM, Gerhardt GA, Cadenas E and Laranjinha J. PNAS 102(48):17483-8, 2005.
  2. Restoring lost cognitive function. Berger TA, Ahuja A, Courellis SH, Deadwyler SA, Erinjinppurath G, Gerhardt GA, Gholmieh G, Granacki JJ, Hampson R, Hsaio MC, LaCoss J, Marmarelis VZ, Nasiatka P, Srinivasan V, Song D, Tanguay AR and Wills J. IEEE Eng Med Biol Mag 24(5): 30-44, 2005.
  3. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Gash DM, Zhang Z, Ai Y, Grondin R, Coffey R, and Gerhardt GA. Ann Neurol 58(2):224-33, 2005.
  4. Neurochemical investigations of dopamine neural systems in iron-regulatory protein 2 (IRP-2) knockout mice. Salvatore MF, Fisher B, Surgener SP, Gerhardt GA, and Roualut T. Mol Brain Res 139:341-347, 2005.
  5. Electrochemical measurement of endogenously-produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes. Ferreira NR, Ledo A, Frade JG, Gerhardt GA, Laranjinha J, and Barbosa RM. Analytica Chimica Acta 535 (1-2):1-7, 2005.
  6. Improvement of bilateral motor functions in patients with Parkinson’s disease through the unilateral intraputamenal infusion of glial cell line-derived neurotrophic factor. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB. J Neurosurg 102(2):216-222, 2005.
  7. Research on Parkinson’s disease. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB. J Neurosurg 102(2):401, 2005.
  8. Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core. Glaser PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA. Psychopharmacology 178(2-3):250-8, 2005.
  9. Electrochemical measurement of endogenously-produced nitric oxide in brain slices using nafion/o-phenylenediamine modified carbon fiber microelectrodes. Ferreira NR, Ledo A, Frade JG, Gerhardt GA, Laranjinha J, and Barbosa RM. Analytica Chimica Acta (in press), 2005.
  10. In vivo electrochemical studies of d-amphetamine and d,l-amphetamine-induced dopamine release in the rat striatum and nucleus accumbens core. Glaser PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA. Psychopharmacology (in press), 2005.
  11. Transport mechanisms governing serotonin clearance in vivo revealed by high speed chronoamperometry. Daws LC, Montanez S, Owens WA, Gould GG, Frazer A, Toney GM and Gerhardt GA. J Neurosci Meth (in press), 2005.
  12. L-lactate measures in brain tissue with ceramic-based multisite microelectrodes. Burmeister JJ, Palmer M and Gerhardt GA. Biosensors and Bioelectronics 20:1772-1779, 2005.

Publications (2004)

  1. Aged related changes in the dynamics of potassium-evoked l-glutamate release in the striatum of Fischer 344 rats. Nickell J, Pomerleau F, Allen J and Gerhardt GA. J Neural Transm. 112(1):87-96, 2004.
  2. Amperometric measurement of extracellular choline: A method for the detection of rapid changes in cholinergic transmission. Parikh V, Sarter M, Bruno JP, Pomerleau F, Huettl P, and Gerhardt GA. Eur J Neurosci. 20(6):1545-54., 2004.
  3. Ceramic-based multisite electrode arrays for chronic single-neuron recording. Moxon, K.A., Leiser S., Gerhardt GA and Chapin J.K. IEEE Transaction on Biomedical Engineering 51(4):647-656, 2004.

Publications (2003)

  1. Real time in vivo measures of l-glutamate in the rat central nervous system using ceramic-based multisite microelectrode arrays. Pomerleau F, Day BK, Huettl P, Burmeister JJ, and Gerhardt GA. Ann NY Acad Sci. 1003:454-457, 2003.
  2. Ceramic-based multisite microelectrode arrays for in vivo electrochemical recordings of glutamate and other neurochemicals. Burmeister JJ and Gerhardt GA. Trends Analyt Chem 22(9):503-508, 2003.
  3. Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of freely-moving rats. Sabeti J, Gerhardt GA and Zahniser NR. Neurosci Lett 343(1):9-12, 2003.
  4. Ceramic-based multisite microelectrode array for rapid choline measures in brain tissue. Burmeister JJ, Palmer MR and Gerhardt GA. Analytica Chimica Acta 481:65-74, 2003.

Publications (2002)

  1. Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region in vivo. Montanez, S., Daws, LC, Gould, GG, Gerhardt GA and Frazer, A. Brain Res 955(1-2):236-44, 2002.
  2. Quantitative analysis of striatal clearance of exogenous dopamine, recorded by chronoamperometry in the freely-moving rat. Sabeti J, Adams CE, Gerhardt GA, and Zahniser, NR. J Neurosci Meth 121(1):41-52, 2002.
  3. Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS. Burmeister, JJ, Pomerleau F, Palmer M, Day BK, Huettl P and Gerhardt GA. J Neurosci Meth 119(2):163-171, 2002.

Publications (2001)

  1. Effects of recording media composition on the response of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry. Gerhardt GA and Hoffman, A.F. J. Neurosci. Meth. 109(1):13-21, 2001.
  2. Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferents from the measurement of L-glutamate and other Analytes. Burmeister, J.J. and Gerhardt GA. Anal. Chem., 73(5):1037-1042, 2001.

Earlier Publications

  1. Receptor-Mediated Regulation of Serotonin Clearance in Rat Hippocampus in vivoa. Daws, L.C., Gould, G.G., Teicher, S.D., Gerhardt GA, and Frazer, A. 5-HT1B J. Neurochem. 75(5):2113-2122, 2000.
  2. Ceramic-Based Multisite Microelectrodes for Electrochemical Recordings. Burmeister, J.J., Moxon, K., and Gerhardt GA. Anal. Chem., 72(1):187-192, 2000.
  3. In vivo microdialysis studies of age-related alterations in potassium-evoked overflow of dopamine in the dorsal striatum of Fischer 344 rats. Stanford, J.A., Giardina, K., and Gerhardt GA. Int. J. Develop. Neurosci. (18)4-5:411-416, 2000.
  4. Differences in the pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study. Hoffman, A.F. and Gerhardt GA. JPET, 289:455-463, 1999.
  5. In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. Zahniser, N.R., Larson, G.A., and Gerhardt GA. JPET, 289:266-277, 1999.
  6. Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely moving rats. Gerhardt GA, Ksir, C., Pivik, C., Dickinson, S.D., Sabeti, J., and Zahniser, N.R. J. Neurosci. Meth., 87:67-76, 1999.
  7. Age-related changes in the capacity, rate and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: An in vivo electrochemical study. Hebert, M.A. and Gerhardt GA. JPET, 288:879-887, 1999.
  8. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. Hoffman, A.F., Lupica, C.R., and Gerhardt GA. J. Pharmacol. Exp. Therapeut., 287:487-496, 1998.
  9. In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. David, D., Zahniser, N.R., Hoffer, B.J., and Gerhardt GA. Exp. Neurol., 153:277-286, 1998.
  10. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. Daws, L.C., Toney, G.M., Gerhardt GA, and Frazer, A. JPET, 286:967-976, 1998.
  11. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-OHDA lesions. Hoffman, A.F. and Gerhardt GA. J. Neurochem., 70:179-189, 1998.
  12. In vivo electrochemical measurements of serotonin clearance in rat striatum: effects of neonatal 6-hydroxydopamine-induced serotonin hyperinnervation and serotonin uptake inhibitors. Luthman, J., Friedemann, M.N., Hoffer, B.J., and Gerhardt GA. J. Neural Tran., 104:379-397, 1997.
  13. Effects of ethanol on striatal dopamine overflow and clearance: An in vivo electrochemical study. Wang, Y., Palmer, M.R., Cline, E.J., and Gerhardt GA. Alcohol, 14:593-601, 1997.
  14. In vivo chronoamperometric measurements of exogenously applied serotonin in the rat dentate gyrus. Daws, L.C., Toney, G.M., Davis, D.J., Gerhardt GA, and Frazer, A. J. Neurosci. Meth., 78:139-150, 1997.
  15. In vivo microdialysis studies of somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF. Hoffman, A.F., van Horne, C.G., Eken, S., Hoffer, B.J. and Gerhardt G. Exp. Neurology, 147:130-141, 1997.
  16. Functional effects of GDNF in normal rat striatum: Presynaptic studies using in vivo electrochemisitry and microdialysis. Hebert, M.A., van Horne, C.G., Hoffer, B.J., and Gerhardt GA. J. Pharmacol. Exp. Therapeut., 279:1181-1190, 1996.
  17. o-Phenylenediamine modified carbon fiber electrodes for the detection of nitric oxide. Friedemann, M.N., Robinson, S.W. and Gerhardt GA. Analytical Chem., 68:2621-2628, 1996.
  18. Fabrication and characterization of sputtered-carbon microelectrode arrays. Sreenivas, G., Ang, S.S., Fritsch-Faules, I., Gerhardt G, and Woodward, D.J. Analytical Chemistry, 68:1858-1864, 1996.
  19. In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat. Friedemann, M.N. and Gerhardt GA.. Exp. Neurol., 138:53-63, 1996.
  20. In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys. Gerhardt GA, Cass, W.A., Hudson, J., Henson, M., Zhang, Z., Ovadia, A., Ketonen, E., Hoffer, B.J., and Gash, D.M. J. Neurochem., 66:579-588, 1996.
  21. In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens. Cass, W.A. and Gerhardt GA.. J. Neurochem., 65:201-207, 1995.
  22. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Hudson, J., Granholm, A-C., Gerhardt GA, Henry, M.A., Hoffman, A., Biddle, P., Leela, N.S., Mackerlova, L., Lile, J.D., Collins, F., and Hoffer, B.J. Brain Res. Bull., 36:425-432, 1995.
  23. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Hoffer, B.J., Hoffman, A., Bowenkamp, K., Huettl, P., Hudson, J., Martin, D., Line, L-F. and Gerhardt GA.. Neurosci. Lett. 182:107-111, 1994.
  24. Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake. Cass, W.A. and Gerhardt GA.. Neurosci. Lett., 176:259-263, 1994.
  25. In vivo electrochemical measurements of exogenous dopamine clearance in normal and neonatal 6-hydroxydopamine-treated rat striatum. Luthman, J., Friedemann, M.N., Hoffer, B.J. and Gerhardt GA.. Exp. Neurol., 122:273-282, 1993.
  26. In vivo electrochemical measurements and electrophysiological studies of rat striatum following neonatal 6-hydroxydopamine treatment. Luthman, J., Friedemann, M., Bickford, P., Olson, L., Hoffer, B.J. and Gerhardt GA.. Neuroscience 52:677-687, 1993.
  27. Age-induced changes in single locus coeruleus brain transplants grown in oculo: An in vivo electrochemical study. Gerhardt GA, Palmer, M.R. and Granholm, A-Ch. Neurobiology of Aging 12:487-494, 1991.
  28. Electrically-evoked release of norepinephrine in the rat cerebellum: An in vivo electrochemical and electrophysiological study. Bickford-Wimer, P., Pang, K., Rose, G.M. and Gerhardt GA.. Brain Res. 558:305-311, 1991.
  29. Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS. van Horne, C., Bement, B., Hoffer, B.J. and Gerhardt GA.. Neuroscience Lett., 120:249-252, 1990.
  30. The effects of cholecystokinin (CCK-8) on dopamine containing nerve terminals in the caudate nucleus and nucleus accumbens of the anesthetized rat: An in vivo -electrochemical study. Gerhardt GA, Friedemann, M., Brodie, M.S., Vickroy, T.W., Gratton, A.P., Hoffer, B.J. and Rose, G.M. Brain Res., 499: 157-163, 1989.
  31. High resolution spatio-temporal analysis of chemical signals using microelectrochemical electrodes. Moore, P.A., Gerhardt GA, and Atema, J. Chem. Senses, 14 (6): 829-840, 1989.
  32. Direct determination of unconjugated HVA in human plasma filtrates by HPLC coupled with dual-electrode coulometric electrochemical detection. Gerhardt GA, Drebing, C.J., Stephen, C. and Freedman, R. Biomed. Chromatog., 3(3): 105-109, 1989.
  33. In vivo electrochemical studies of the effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the neostriatum of the anesthetized rat. Friedemann, M. and Gerhardt GA.. Proc. West Pharmacol. Soc. 32: 143-147, 1989.
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